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sr57227a  (MedChemExpress)


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    MedChemExpress sr57227a
    Sr57227a, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sr57227a/product/MedChemExpress
    Average 92 stars, based on 2 article reviews
    sr57227a - by Bioz Stars, 2026-02
    92/100 stars

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    Role of 5HT3 receptor antagonist (ondansetron) in extinction learning in SPS rats. Two cohorts of animals were used in these experiments and each cohort consisted of three groups. All animals went through the SPS procedure one week before the start of the experiments. Habituation and conditioning took place in context A. Training was performed in context A for the contextual cohort (a) and context B for the cued cohort (b). The control group received intra-mPFC microinjections of the vehicle after each training session. The other two groups received either ondansetron or a 5HT3 agonist (SR 57227A) after the training sessions. Data are presented as Mean±SEM. ** P <0.01, *** P <0.001, **** P <0.0001 as compared with the SPS group

    Journal: Iranian Journal of Basic Medical Sciences

    Article Title: In vivo blockade of 5HT3 receptors in the infralimbic medial prefrontal cortex enhances fear extinction in a rat model of PTSD

    doi: 10.22038/ijbms.2021.54299.12197

    Figure Lengend Snippet: Role of 5HT3 receptor antagonist (ondansetron) in extinction learning in SPS rats. Two cohorts of animals were used in these experiments and each cohort consisted of three groups. All animals went through the SPS procedure one week before the start of the experiments. Habituation and conditioning took place in context A. Training was performed in context A for the contextual cohort (a) and context B for the cued cohort (b). The control group received intra-mPFC microinjections of the vehicle after each training session. The other two groups received either ondansetron or a 5HT3 agonist (SR 57227A) after the training sessions. Data are presented as Mean±SEM. ** P <0.01, *** P <0.001, **** P <0.0001 as compared with the SPS group

    Article Snippet: Drugs SR 57227A (5-HT3 agonist) and Ondansetron (5-HT3 antagonist) were obtained from sigma- Aldrich (Sigma-Aldrich, Taufkirchen, Germany).

    Techniques:

    Effect of 5HT3 receptor antagonism on EPM test in SPS rats. Anxiety was tested one day after the last training session in contextual (a) and cued (b) cohorts of rats. Each cohort consisted of three groups. The first group was an SPS group that received intra-mPFC microinjections of the vehicle after each training session. The second group was injected with ondansetron (5HT3 antagonist), and the third group was treated with both ondansetron and SR 57227A (5HT3 agonist) after the training sessions. The contextual cohort had gone under contextual extinction tests and the cued cohort had experienced the cued extinction experiments before the EPM tests. Data are expressed as Mean±SEM

    Journal: Iranian Journal of Basic Medical Sciences

    Article Title: In vivo blockade of 5HT3 receptors in the infralimbic medial prefrontal cortex enhances fear extinction in a rat model of PTSD

    doi: 10.22038/ijbms.2021.54299.12197

    Figure Lengend Snippet: Effect of 5HT3 receptor antagonism on EPM test in SPS rats. Anxiety was tested one day after the last training session in contextual (a) and cued (b) cohorts of rats. Each cohort consisted of three groups. The first group was an SPS group that received intra-mPFC microinjections of the vehicle after each training session. The second group was injected with ondansetron (5HT3 antagonist), and the third group was treated with both ondansetron and SR 57227A (5HT3 agonist) after the training sessions. The contextual cohort had gone under contextual extinction tests and the cued cohort had experienced the cued extinction experiments before the EPM tests. Data are expressed as Mean±SEM

    Article Snippet: Drugs SR 57227A (5-HT3 agonist) and Ondansetron (5-HT3 antagonist) were obtained from sigma- Aldrich (Sigma-Aldrich, Taufkirchen, Germany).

    Techniques: Injection

    Effect of ondansetron on locomotor activity in the open field apparatus in SPS rats. Total square crossing was measured as the locomotor index. Two cohorts of animals were tested 24 hr after the last extinction test. The contextual cohort groups had previously passed the contextual extinction tests and consisted of SPS, ondansetron, and ondansetron plus SR 57227A (5HT3 agonist) groups (a). The cued cohort groups had the same corresponding groups and had experienced the cued extinction sessions (b). Data are displayed as Mean±SEM

    Journal: Iranian Journal of Basic Medical Sciences

    Article Title: In vivo blockade of 5HT3 receptors in the infralimbic medial prefrontal cortex enhances fear extinction in a rat model of PTSD

    doi: 10.22038/ijbms.2021.54299.12197

    Figure Lengend Snippet: Effect of ondansetron on locomotor activity in the open field apparatus in SPS rats. Total square crossing was measured as the locomotor index. Two cohorts of animals were tested 24 hr after the last extinction test. The contextual cohort groups had previously passed the contextual extinction tests and consisted of SPS, ondansetron, and ondansetron plus SR 57227A (5HT3 agonist) groups (a). The cued cohort groups had the same corresponding groups and had experienced the cued extinction sessions (b). Data are displayed as Mean±SEM

    Article Snippet: Drugs SR 57227A (5-HT3 agonist) and Ondansetron (5-HT3 antagonist) were obtained from sigma- Aldrich (Sigma-Aldrich, Taufkirchen, Germany).

    Techniques: Activity Assay